Ethoxidol^®

Ethoxidol^® – promotes cell survival, reduces the effects of ischemia (lack of blood supply) and helps restore neurological and mental activity.

Indications for use:

• coronary heart disease (as part of complex therapy);
• complex therapy of ischemic stroke;
• dyscirculatory encephalopathy;
• mild and moderate cognitive disorders.

Key advantages:

• restores its own antioxidant system of oragnism^1-4;
• gives 2.5 times more energy (ATP^*) to cells with ischemia^{1-2, 6-11};
• penetrates the blood-brain barrier better^3-5;
• has an antihypoxic effect^3,4,6,14;
• improves rheological properties of blood^3,4,6,14;
• has a hypolipidemic effect^3,4,6,14;
• does not cause cell death in conditions of ischemia and hypoxia^7,11;
• allows to compensate for malate deficiency in ischemia^7,12,13.

^* ATP - adenosine triphosphate.

¹ Katsunori Shijo. Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. Neurochem Int. 2017 Jan; 102: 66–78.

² Cerdán S. Twenty-seven Years of Cerebral Pyruvate Recycling. Neurochem Res. 2017 Jun;42(6):1621-1628.

³ Instructions for medical use of the drug Ethoxidol^® solution for intravenous and intramuscular administration.

⁴ Instructions for medical use of the drug Ethoxidol^® chewable tablets.

⁵ Amber Dahlin. Expression Profiling of the Solute Carrier Gene Family in the Mouse Brain. The Journal of Pharmacology and Experimental Therapeutics. 2009.

⁶ Dadasheva M.N., Taranenko N.Yu., et al. Pathogenetic therapy with a new domestic antioxidant Ethoxidol in cerebrovascular disease. Bulletin of Family Medicine No. 1-2 – 2015.

⁷ Chinopoulos C. Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex. J Neurosci Res. 2013 Aug;91(8):1030-43.

⁸ Pyruvate recycling in cultured neurons from cerebellum. J Neurosci Res. 2007 Nov 15;85(15):3318-25.

⁹ Bricker DK. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 2012.

¹⁰ Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study. Neurochem Int. 2017 Jan; 102: 66–78.

¹¹ Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol 286: F749–F759, 2004.

¹² L-Malate's Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats 2016.

¹³ Intravascular volume therapy in adults Guidelines from the Association of the Scientific Medical Societies in Germany 2016.

¹⁴ Sernov L.N. et al. The results of the study of a domestic drug, an antioxidant of the second generation – ethoxidol. Ed. and with the participation of: acad. RAS, Prof. Archakova A.I., acad. RAS, merit of a scientist, Prof. D.M.N. Kukesa V.G., Assoc. Dmitrieva D.A. ANO International Association of Clinical Pharmacologists and Pharmacists. 2014.